Myocardial infarct size and mortality in diabetic patients.

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Myocardial infarct size and mortality in diabetic patients.

The mortality rate from myocardial infarction is disproportionately high in diabetic patients. One explanation for this may be that diabetic patients incur more extensive myocardial necrosis. This possibility was examined in a three part study. Firstly, peak serum aspartate aminotransferase concentrations of all diabetic and non-diabetic patients admitted with myocardial infarction over a 16 ye...

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Infarct size, ejection fraction, and mortality in diabetic patients with acute myocardial infarction treated with thrombolytic therapy.

BACKGROUND Diabetic patients with acute myocardial infarction (MI) have higher mortality than nondiabetic patients. The purpose of this study was to examine if larger infarct size explains the higher mortality in diabetic patients with acute ST-segment-elevation MI. METHODS In the CORE trial (n = 2948), subsets of patients underwent quantitative radionuclide measurement of technetium Tc 99m s...

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Haptoglobin genotype determines myocardial infarct size in diabetic mice.

OBJECTIVES We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). BACKGROUND Two common alleles (1 and 2) exist at the Hp locus in humans. The Hp 2 allele is associated with increased MI size in individuals with DM. In vitro, the Hp 2 protein is associated with increased g...

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Reply: relationship between myocardial reperfusion, infarct size, and mortality.

Brener et al. (1) show in a substudy of INFUSE-AMI (Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction) trial that myocardial blush grade (MBG) 2/3 in a relatively small study population of 452 patients is associated with smaller infarct size, less microvascular obstruction, improved ejection fraction as assessed by contrast-enhanced cardia...

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Myocardial Infarct Size and Location

Recent infarcts were compared with the anatomic boundaries of the involved vascular bed in human hearts to determine the amount and location of necrosis in relation to the myocardium at risk. The coronary arteries were injected with BaSo4 in 18 human hearts with 3-16-day-old infarcts. Thin (3-4-mm) slices were cut at 10-15-mm intervals, photographed, x-rayed and used for histologic analysis. In...

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ژورنال

عنوان ژورنال: Heart

سال: 1985

ISSN: 1355-6037

DOI: 10.1136/hrt.54.5.466